DETAILED NOTES ON PK MONKEY

MPDL3280A was generated at Genentech Inc. and was presented in a transparent liquid form with the in vivo monkey PK examine. PRO304397, a CHO cell-derived reverse chimera and mouse IgG2a DANA antibody from murine PD-L1, was utilized to evaluate the PK/PD romance in mice in addition to in the mouse tissue distribution and tumor penetration research.